Impact factor 3. International Journal of Biological Sciences. International Journal of Medical Sciences.
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P reclinical studies show that bisphosphonates may have antitumor activity in addition to their ability to reduce osteoclast-mediated bone resorption. Many randomized controlled trials have evaluated the role of bisphosphonates in the adjuvant setting of breast cancer and have shown a beneficial effect on bone loss prevention. Considering the notable accumulation of randomized trials, the authors performed a meta-analysis of these to address whether the use of bisphosphonates in the adjuvant setting of breast cancer might have any effect on the natural course of the disease.
Salvage therapy with bendamustine for temozolomide refractory recurrent anaplastic gliomas: A Prospective phase II trial. Upsampling dynamic contrast enhanced MRI. Proceedings - International Symposium on Biomedical Imaging.
J Breast Cancer. Published online December 26, All rights reserved.
Nine of 14 patients had confirmed pCR with the regimen, which was generally well tolerated. The findings are consistent with those of a larger patient series reported recently showing a high rate of pCR in patients with triple-negative locally advanced breast cancer treated with neoadjuvant platinum-docetaxel chemotherapy. The favorable prognostic outcomes associated with pCR, including survival, warrant larger, prospective investigations of the regimen in patients with triple-negative breast cancer, German investigators reported here at the American Society of Clinical Oncology's Breast Cancer Symposium.
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